Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However,\nresveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare\na resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents\nand oils that could be harmful to the human body and the environment. Hence, we propose\nthe use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol.\nA dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement,\nstability in solution and cream dosage forms. We have also developed a high performance liquid\nchromatography method to measure the resveratrol within the final product. PAMAM dendrimers\nincreased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore,\nthis product would be water based ââ?¬Ë?greenââ?¬â?¢ formulation devoid of harsh organic solvents and oils\nand can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to\nincrease overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation\nwas successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation\nin anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex\ncould also be added to other product forms for additional purposes and applications.
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